Biographical Sketch

Marc Bonten (1964) received his MD at the University of Maastricht in 1991 and his PhD, at the same university, in 1994 (The role of colonization of the upper intestinal tract in the pathogenesis of ventilator-associated pneumonia). He finished his training for Internal Medicine in 2002 (University Medical Center Utrecht) and for Infectious Diseases in 2002, also at the UMC Utrecht). In 2003 he was appointed professor of Molecular Epidemiology of Infectious Diseases with a shared position within the departments of Internal Medicine & Dermatology and the Julius Center. Since 2004 he is head of the (sub-)department of Hospital Hygiene and Infection Prevention, within the department of Medical Microbiology. He is a 2006 VICI laureate. As of December 2007, he has supervised 10 PhD students, and is involved in the supervision of 18 PhD students.

Interests and Focus

Marc Bonten is actively involved in 4 research areas, that are all interacting. 1. Molecular epidemiology of antibiotic resistance, with a focus on CC17 Enterococcus faecium, MRSA and P. aeruginosa. His group is heading the 6th FP Strategic Research Project ACE, as well as a cluster-randomized ICU intervention study as part of the 6th FP Integrated Project MOSAR. (group composition: 4 post-docs, 11 PhD students, 2 technicians) 2. Prevention of nosocomial infections, with a strong focus on ICU-acquired infections. (group composition: 5 PhD students) 3. Mathematical modelling of antibiotic resistance, with a focus on MRSA and new methods for evaluating the spread of pathogens within hospital settings. (group composition: 2 post-docs, 1 PhD student) 4. Vaccination. A large randomized trial for pneumococcal vaccination of elderly is currently prepared. (group composition: 1 PhD)

Key Publications

• An algorithm to estimate the importance of bacterial acquisition routes in

  Bootsma MC, Bonten MJ, Nijssen S, Fluit AC, Diekmann O. Am J Epidemiol. , 2007 Oct 1;166(7):841-51.

• A Bayesian decision-support system for diagnosing ventilator-associated

  Schurink CA, Visscher S, Lucas PJ, van Leeuwen HJ, Buskens E, Hoff RG, Intensive Care Med. , 2007 Aug;33(8):1379-86.

• Quantifying the relationship between Staphylococcus aureus bacteremia and S.

  Ekkelenkamp MB, Verhoef J, Bonten MJ. Clin Infect Dis. , 2007 Jun 1;44(11):1457-9.

• Insertion sequence-driven diversification creates a globally dispersed emerging

  Leavis HL, Willems RJ, van Wamel WJ, Schuren FH, Caspers MP, Bonten MJ. PLoS Pathog. , 2007 Jan;3(1):e7.

• Open and closed endotracheal suction systems in mechanically ventilated intensive

  Jongerden IP, Rovers MM, Grypdonck MH, Bonten MJ. Crit Care Med. , 2007 Jan;35(1):260-70.

• Effectiveness of early switch from intravenous to oral antibiotics in severe

  Oosterheert JJ, Bonten MJ, Schneider MM, Buskens E, Lammers JW, Hustinx WM, BMJ. , 2006 Dec 9;333(7580):1193.