Cohorts and projects

The UMC Utrecht Julius Center coordinates and participates in several large research cohorts. These cohorts are an important base for research and provide ample opportunities for obtaining financial research support. Furthermore, the projects of the GP-network Utrecht and the Utrecht Health Project are intended to create an infrastructure in which research questions on efficacy and effectiveness of healthcare and effects of (local) healthcare policy can be answered. The latter is of major importance for increasing the expertise in the areas of healthcare improvement, extramural healthcare and general practice.

The major cohorts are:

GENERAL

	AGIS Health database The AGIS Health Database, currently called Achmea Health Base, is a health insurance company registry containing all healthcare procedures carried out in the last ten years involving 1.2 million health insured persons.

	ALL-IN Welcome to the website of the ALL-IN project. ALL-IN stands for: Management of Atrial fibriLLation INcluding tailoring of anticoagulation in patients from primary care.

	Apotheker zonder d'rop (Dutch) In this project, we create a new feature: the pharmacist-farmacotherapeut in general practice.

	Electronic patient records communication disorders Multidisciplinary evaluation of speech and language problems in children.

	The Escher project Science-driven drug regulation and innovative research throughout phased drug development.

	Julius General Practitioners Network The Julius Primary Care Network serves as a database source for primary care based research, for quality management projects and healthcare innovation projects.

	The Mondriaan project A national data network containing healthcare and research databases to fuel pharmaceutical research in The Netherlands.

	Transitional Incident Prevention Program - TIPP! The aim of the project is to design and evaluate a Transitional Incident Prevention Program (TIPP!) directed at improving patient safety in healthcare by reducing transitional incidents.

	PCR-MN PCR-MN (Psychiatric Case Registry Midden Nederland) is an anonymous psychiatric case registry in the central region of The Netherlands.

	PROVIDI PROVIDI is a cohort of ca. 16,000 patients who have undergone a chest multislice Computed Tomography (msCT) scan for diagnostic reasons.

	SIS The objective of the SCOPE Intervention Study is to measure the effect of a culture questionnaire either solely or combined with a workshop on the safety behaviour and culture in general practice.

	SPARK The SPARK, Structured Problem Analysis of Raising Kids, is a structured and validated tool used to support parents in parenting and developmental problems of toddlers.

	Utrecht Health Project (LRGP) The Utrecht Health Project (or Leidsche Rijn GezondheidsProject (LRGP) is a population study of residents of the Leidsche Rijn, a new residential area in Utrecht.

	The public-private IMI GetReal consortium aims to improve the efficiency of the medicine development process by better incorporating estimates of relative effectiveness into drug development and to enrich decision-making by regulatory authorities and HTA bodies.

CARDIOVASCULAR DISEASES

The Utrecht Cardiovascular Cohort (UCC) (in Dutch)

	The ADDITION study The ADDITION (Anglo-Danish-Dutch study of Intensive Treatment In peOple with screeN-detected diabetes in primary care)-Netherlands cohort consists of 498 patients with screen-detected type 2 diabetes mellitus.

	ARYA The Atherosclerosis Risk in Young Adults (ARYA) study is an unselected birth cohort of 750 persons born between 1970 and 1973 in and around the city of Utrecht.

	Champ study The CHAMP project will summarize the available evidence on activities that aim towards a rational and cost-effective use of antibiotic management of respiratory infections in primary care.

	EFFIMODI: EFFIciënte MOnitoring van DIabetes (in Dutch) Reducing checks in patients with Type 2 Diabetes Mellitus.

	EPIC-NL European Prospective Investigation into Cancer and Nutrition (EPIC)

	EVA - The ‘EVAluation biomarkers in VTE study’ (EVA) study. ( Dutch only ) In 2016 and 2017 the cardiovasculair study group in primary care of the Julius Center (UMC Utrecht) idoes research on new D-dimer tests together with general practitioners (GPs) and a number of laboratories. The GP can rule out thrombosis in his/her own office with a point-of-care D-dimer test and contribute therefore to useful, economical and patient friendly health care.

	HEART Score The HEART score is a newly developed scoring system for patients presenting with chest pain at the emergency room. By assigning zero, one, or two points — towards a patient history, ECG abnormalities, the patient's age, any risk factors present, and troponin measurement— patients receive a score on a scale of 0‒10. The HEART score has been validated in several studies and has proven to be a powerful, easy, and above all practical instrument to separate patients into a low, medium and high risk groups. For more information please visit www.heartscore.nl.

	IRIS studie (in Dutch) IRIS is a web counseling service which can actively contribute to the change in observed risk factors for heart disease. Reducing checks in patients with Type 2 Diabetes Mellitus.

	IJSCO The IJSCO (IJsselstein Screening for Central Obesity to detect metabolic syndrome) cohort consists of 473 people with screen-detected metabolic syndrome (MetS).

	Integrate study (Dutch) The INTEGRATE study evaluates the (cost-)effectiveness and implementation of the NHG-guideline ‘Prevention of cardiometabolic diseases’ combined with treatment of risk factors.

	MIND-TIA Markers in the Diagnosis of TIA. A primary healthcare project studying the diagnosis of Transient Ischaemic Attack (TIA).

	NUZO (in Dutch) Utrecht Network Care for Elderly (Netwerk Utrecht Zorg voor Ouderen)

	PEDNET The PedNet Haemophilia Registry is a collaborative effort of the European PEDiatric NETwork for hemophilia management.

	PROFIEL study PROFIEL is a longitudinal population-based study among approximately 600 older men and women.

	SMART SMART is an ongoing, prospective, single-center cohort study of patients with cardiovascular risk factors or clinically manifested arterial disease.

	Sportcor (in Dutch) Research into the cause of sudden death in sports.

	Transfusion Technology Assessment (TTA) The goal of TTA is to provide scientific evidence to support informed decision making by Sanquin management and national and international policymakers.

	USE: intima media thickness The USE-IMT Study was initiated to provide evidence of whether or not the intima media thickness measurement of the carotid artery should be added to current cardiovascular risk prediction scores.

	Vasculair preventieprogramma SMART (in Dutch) Care part SMART. The care part offers a vascular screening and formulates a multidisciplinary therapeutic advice.
	The Utrecht Cardiovascular Cohort (UCC) (in Dutch) The Utrecht Cardiovascular Cohort (UCC) has a standard procedure for collecting medical information on all cardiovascular patients at the UMC Utrecht. Those patients are then monitored for many years within the framework of care and research.

INFECTIOUS DISEASES

	CAPiTA (in Dutch) A vaccination study in seniors.

	COMBACTE The IMI-funded COMBACTE project (Combating Bacterial Resistance in Europe) is a collaboration between research institutions and pharmaceutical companies to develop and test new antibiotics.

	GRACE This project aims to integrate and coordinate the activities of physicians and scientists from many institutions in 14 European countries to combat antibiotic resistance in community-acquired lower respiratory tract infections.

	Netherlands Amniotic Fluid (NAF) cohort The Netherlands Amniotic Fluid (NAF) cohort is an ongoing birth cohort focusing on the role of amniotic fluid inflammation in relation to respiratory tract infections during the first years of life.

	PIAMA (in Dutch) The PIAMA research focuses on the causes and the prevention of asthma and allergy in children. PIAMA stands for "Prevention and Incidence of Asthma and Mite Allergy.

	R-GNOSIS The R-GNOSIS (Resistance in Gram-Negative Organisms: Studying Intervention Strategies) project combines 5 international clinical intervention studies.

	RIVAR Twelve Dutch pilot-hospitals with Neonatal Intensive Units and associated post IC/HC hospitals will participate in an implementation project of a hospital-based RV vaccination program for high-risk infants (RIVAR-program).

	Utrecht Center for Infection Dynamics (UCID) The Utrecht Center for Infection Dynamics (UCID) is a center of excellence for interdisciplinary research in infectious diseases.

	RotaFam (in Dutch) This study aims to assess the relative contribution of households in driving rotavirus epidemics by using a mathematical model and estimating rotavirus vaccination impact.
	Netherlands Centre for One Health Netherlands Centre for One Health (NCOH) aims for an integrated One Health approach to tackle the global risk of infectious diseases.

CANCER

	DENSE (in Dutch) The DENSE study is scientific research conducted within the existing breast cancer screening.

	DOM The DOM cohort is a cohort of 50,000 healthy women, living in Utrecht and surrounds.

	EPIC-NL EPIC-NL is the Dutch contribution to European Prospective Investigation into Cancer and Nutrition (EPIC).

	PACT studie (in Dutch) The PACT trial is a scientific study of the effects of exercise in the treatment of breast or colon cancer.

	PAM (in Dutch) The PAM study is a scientific study which examines the effect of physical exercise on cognitive problems (i.e. memory and concentration) in breast cancer patients.

	PREDICT This is a prospective study in which consecutive general practice attendees, in six European countries, are recruited and followed up for the prevalence of depression after six and twelve months.

	PROSPECT-EPIC The Prospect-EPIC study is one of the two Dutch cohorts participating in the European Prospective Investigation into Cancer and Nutrition.

METHODOLOGY

No cohorts and projects