R-GNOSIS

Decolonization strategies in Intensive Care

Call for participants for a new European mulicentre trial
Comparing SDD / SOD / chlorhexidine mouthwash

The R-GNOSIS (Resistance in Gram-Negative Organisms: Studying Intervention Strategies) project combines 5 international clinical intervention studies to determine the efficacy and effectiveness of cutting-edge interventions to reduce acquisition, carriage, infection and spread of Multi-Drug Resistant Gram-negative Bacteria (MDR-GNB).

With the “decolonization strategies in intensive care” study we initiate a new European wide multicentre ICU trial to determine the effect and safety of three decolonization strategies:

• Selective Digestive tract Decontamination (SDD)
• Selective Oropharyngeal Decontamination (SOD)
• Chlorhexidine mouthwash (Oro-CHX)

From 2013-2015 we plan to include over 10.000 patients in 15 ICUs across Europe. Primary outcome will be the effect of SDD / SOD and chlorhexidine mouthwash on the rate of ICU acquired bacteremia and 28-day mortality. In addition, the effect on colonization rates and prevalence of multi drug resistant gram negative bacteria will be evaluated.

Currently we are looking for European ICUs interested in participating in this trial. More information about the study and objectives can be found in the attached tentative research protocol. The European procurement document states terms and conditions and the application procedure for participation. Please visit these pages when you are interested in participating in this trial and return the completed Tender Document (MS excel file). 

More information
Should you have any further questions, do not hesitate to contact us for further information or visit www.r-gnosis.eu.

Bastiaan H.J. Wittekamp
Co-ordinating investigator
University Medical Centre Utrecht

Prof. M.J.M. Bonten, MD, PhD
Professor of Molecular Epidemiology of Infectious Diseases
Principle investigator and head of R-GNOSIS
University Medical Centre Utrecht

Prof. C. Brun-Buisson
Principle investigator
Hospital Henri Mondor, Université Paris-Est, Créteil